IL-4 modulate the tumor microenvironment and response to cancer therapies

Targeting IL4/IL4R for the treatment of epithelial cancer metastasis

Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma


Interleukin-4 receptor targeted immunotherapy of human bladder cancer in animal models


Expression and structure of interleukin 4 receptors in primary meningeal tumors

Expression and structure of interleukin 4 receptor (IL-4R) complex in human invasive pituitary adenomas

Cytotoxins directed at interleukin-4 receptors as therapy for human brain tumors.

Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma

Convection-enhanced Delivery of Free Gadolinium with the Experimental Chemotherapeutic Agent PRX321

Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy

In situ expression of interleukin-4 (IL-4) receptors in human brain tumors and cytotoxicity of a recombinant IL-4 cytotoxin in primary glioblastoma cell cultures

IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein

Interleukin-4-Pseudomonas exotoxin chimeric fusion protein for malignant
glioma therapy

Convection-Enhanced Drug Delivery of Interleukin-4 Pseudomonas Exotoxin (PRX321): Increased Distribution and Magnetic Resonance Monitoring

Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins - Development of a Recombinant Interleukin-4-Pseudomonas Exotoxin for Therapy of Glioblastoma

Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein

Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma

A Review of Studies on Targeting Interleukin 4 Receptor for Central Nervous System Malignancy

Long term survival in a patient with recurrent malignant glioma treated with intratumoral infusion of an IL4-targeted toxin (NBI-3001)

Clinical Studies with Targeted Toxins in Malignant Glioma

Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma

The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy

Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin
(NBI-3001) in patients with recurrent malignant glioma

A mathematical model of the impact of infused targeted cytotoxic agents on brain tumours: implications for detection, design and delivery


IL-4 modulate the tumor microenvironment and response to cancer therapies

Targeting IL4/IL4R for the treatment of epithelial cancer metastasis

Lessons from immunology: IL4R directly promotes mammary tumor metastasis

IL4 receptor α mediates enhanced glucose and glutamine metabolism to support breast cancer growth

IL4 receptor ILR4α regulates metastatic colonization by mammary tumors through multiple signaling pathways

Effect of interleukin (IL)-4 cytotoxin on breast tumor growth after in vivo gene transfer of IL-4 receptor alpha chain

Human Breast Carcinoma Cells Express Type II IL-4 Receptors and Are Sensitive to Antitumor Activity of a Chimeric IL-4-Pseudomonas Exotoxin Fusion Protein in
vitro and in vivo         


Targeting of IL-4 and IL-13 receptors for cancer therapy

Crucial role of interleukin-4 in the survival of colon cancer stem cells

Survivin Is Regulated by Interleukin-4 in Colon Cancer Stem Cells

Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4

IL-4-mediated drug resistance in colon cancer stem cells

Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4


Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer

Epithelial interleukin-4 receptor expression promotes colon tumor growth


Structure, Function, and Targeting of Interleukin 4 Receptors on Human Head and Neck Cancer Cells

Interleukin 4 Receptor-directed Cytotoxin Therapy for Human Head and Neck Squamous Cell Carcinoma in Animal Models

Head and neck cancers, but not benign lesions, express interleukin-4 receptors in situ


IL-4 modulate the tumor microenvironment and response to cancer therapies

Targeting IL4/IL4R for the treatment of epithelial cancer metastasis

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

Immunology: Evolving superkines for selectivity


Phase I Trial of Intravenous IL-4 Pseudomonas Exotoxin Protein (NBI-3001) in Patients with Advanced Solid Tumors That Express the IL-4 Receptor

An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells

Human renal cell carcinoma cells are sensitive to the cytotoxic effect of a chimeric protein composed of human interleukin-4 and Pseudomonas exotoxin


IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma

Hodgkin lymphoma therapy with interleukin-4 receptor–directed cytotoxin in an infiltrating animal model

A recombinant IL-4-Pseudomonas exotoxin inhibits protein synthesis and overcomes apoptosis resistance in human CLL B cells


Interleukin 4 receptor on human lung cancer: a molecular target for cytotoxin therapy


Overexpressed cell surface interleukin-4 receptor molecules can be successfully targeted for antitumor cytotoxin therapy

A chimeric protein comprised of IL-4 and Pseudomonas exotoxin is cytotoxic for activated human lymphocytes

A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin

Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimeric Pseudomonas exotoxin

Internalization property of interleukin-4 receptor alpha chain increases cytotoxic effect of interleukin-4 receptor-targeted cytotoxin in cancer cells

A circularly permuted recombinant interleukin 4 toxin with increased activity

Circularly permuted interleukin 4 retains proliferative and binding activity

Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma

Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells


Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts

Expression of interleukin-4 receptor alpha in human pleural mesothelioma is associated with poor survival and promotion of tumor inflammation


Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1


Expression and targeting of interleukin-4 receptor for primary and advanced ovarian cancer therapy


Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma

Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions

Targeting interleukin-4 receptors for effective pancreatic cancer therapy


Clinical investigation of the role of interleukin-4 and interleukin-13 in the evolution of prostate cancer

Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells

Interleukin-4 in patients with prostate cancer

Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway

Interleukin-4 receptor-targeted cytotoxin therapy of androgen-dependent and -independent prostate carcinoma in xenograft models


IL-4 receptor blockade abrogates satellite cell: rhabdomyosarcoma fusion and prevents tumor establishment

IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma


IL-4 receptor-directed cytotoxin for therapy of AIDS-associated KS tumors

Interleukin-4 receptor expression in vivo on human AIDS-related Kaposi's sarcoma

Interleukin-4 receptor expression on AIDS-associated Kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and Pseudomonas exotoxin

Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model


Identification, characterization, and targeting of IL-4 receptor by IL-4-Pseudomonas exotoxin in mouse models of anaplastic thyroid cancer

Interleukin-4 stimulates papillary thyroid cancer cell survival: implications in patients with thyroid cancer and concomitant Graves' disease

Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10


IL-4 modulate the tumor microenvironment and response to cancer therapies

Targeting IL4/IL4R for the treatment of epithelial cancer metastasis

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor-α

Partners in crime: VEGF and IL-4 conscript tumour-promoting macrophages

IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice

IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins

CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

Human non-small cell lung cancer cells express a type 2 cytokine pattern

Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis

IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients

Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4

Tumor-derived interleukin-4 reduces tumor clearance and deviates the cytokine and granzyme profile of tumor-induced CD8+ T cells

Follicular lymphoma cell niche: identification of a preeminent IL-4-dependent T(FH)-B cell axis

Expression of high-affinity IL-4 receptors on murine tumour infiltrating lymphocytes and their up-regulation by IL-2

Lung Tumor Growth is Stimulated in IFN-γ-/- Mice and Inhibited in IL-4Rα-/- Mice

IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin up-regulation

Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progression

IL-4 inhibits VLA-4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit

IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors

Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4

Evaluations of interferon-γ/interleukin-4 ratio and neutrophil/lymphocyte ratio as prognostic indicators in gastric cancer patients

Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions